62 research outputs found
A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease
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Strong Circadian Rhythms in the Choroid Plexus: Implications for Sleep-Independent Brain Metabolite Clearance
No full textPathogenesis and Therapeutic Strategies in Alzheimer’s Disease: From Brain to Periphery
No full textMagnetic resonance imaging provides evidence of glymphatic drainage from human brain to cervical lymph nodes
No full textChronic cerebral hypoperfusion shifts the equilibrium of amyloid β oligomers to aggregation-prone species with higher molecular weight
No full textThe Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates
No full textDemonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia
No full textMeningeal lymphatic vessels at the skull base drain cerebrospinal fluid
No full text© 2019, The Author(s), under exclusive licence to Springer Nature Limited.Recent work has shown that meningeal lymphatic vessels (mLVs), mainly in the dorsal part of the skull, are involved in the clearance of cerebrospinal fluid (CSF), but the precise route of CSF drainage is still unknown. Here we reveal the importance of mLVs in the basal part of the skull for this process by visualizing their distinct anatomical location and characterizing their specialized morphological features, which facilitate the uptake and drainage of CSF. Unlike dorsal mLVs, basal mLVs have lymphatic valves and capillaries located adjacent to the subarachnoid space in mice. We also show that basal mLVs are hotspots for the clearance of CSF macromolecules and that both mLV integrity and CSF drainage are impaired with ageing. Our findings should increase the understanding of how mLVs contribute to the neuropathophysiological processes that are associated with agein
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